Google Trends data for the first half of 2026 shows PDRN search interest at 1,400% above the same period in 2025, according to multiple skincare industry analytics reports. Polydeoxyribonucleotide — derived from salmon sperm DNA and the active compound in HelioMystique's Recovery Protocol — was named among the top-trending skincare ingredients of 2025 in Google's Year in Search data. The trend reflects growing consumer awareness of bioregulator compounds and the shift in skincare discourse from symptom correction toward root-cause intervention. HelioMystique's Recovery Protocol has incorporated PDRN as a primary compound since launch.